Current Medicinal Chemistry

Atta-ur-Rahman, FRS
Honorary Life Fellow
Kings College
University of Cambridge
Cambridge
UK

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Flavonoids in Atherosclerosis: An Overview of Their Mechanisms of Action

Author(s): G. Siasos, D. Tousoulis, V. Tsigkou, E. Kokkou, E. Oikonomou, M. Vavuranakis, E.K. Basdra, A.G. Papavassiliou, C. Stefanadis.

Abstract:

Polyphenols are composed of a wide variety of molecules that are classified into several categories, according to their chemical type such as phenolic acids, flavonoids, stilbenes, and lignans. Many studies have proven the beneficial effects of flavonoids in atherosclerosis progression and cardiovascular disease. Dietary flavonoids reduce oxidative stress and exert anti-inflammatory actions. Moreover, flavonoids have the ability to avoid the thrombus formation, improve endothelial function, modify lipid levels and regulate glucose metabolism. In the context of this evidence in this review article we summarize the so far acquired knowledge of the most important mechanisms of action of flavonoids in atherosclerosis progression.

Keywords: Antioxidants, atheroscierosis, cardiovascular disease, flavonoids, inflammation.

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Article Details

VOLUME: 20
ISSUE: 21
Year: 2013
Page: [2641 - 2660]
Pages: 20
DOI: 10.2174/0929867311320210003