Biology and Chemistry of Beta Glucan Volume Title: Beta-Glucan, Structure, Chemistry and Specific Application

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β-Glucan is generally considered to be a very safe immunomodulator. It is a well-known biological response modifier (BRM) that has been used as an adjuvant therapy for cancer since 1980, mostly in ...
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Modulation of Photodynamic Therapy by β-Glucan

Pp. 112-130 (19)

Dalia Akramienė

Abstract

Photodynamic therapy (PDT) combines a drug or photosensitizer with a specific type of light to eradicate cancer cells. The cellular damage induced by PDT leads to activation of the DNA damage repair, which is an important factor for modulating tumor sensitivity to this treatment. β-Glucans bind complement receptor 3 on the effector cells, thereby activating them to kill tumor cells during PDT. Here, the hypothesis that adjuvant therapy with β-glucans would increase the efficacy of PDT resulting in pronounced necrosis of PDT-treated tumors and suppression of the DNA damage repair system is discussed.

Keywords:

Immunotherapy, photodynamic therapy, tumor, cancer, glucan, photosensitizer, PDT, complement, CR3, cytotoxicity, NK cells, DNA, damage, repair, PCNA, anti-angiogenetic, inflammatory, response, treatment, lung carcinoma, necrosis, phagocytosis, mice.

Affiliation:

Institute of Physiology and Pharmacology, Medical Academy, Lithuanian University of Health Sciences, A. Mickevičiaus 9, LT-44307 Kaunas, Lithuania.