Biology and Chemistry of Beta Glucan Volume Title: Beta-Glucan, Structure, Chemistry and Specific Application

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β-Glucan is generally considered to be a very safe immunomodulator. It is a well-known biological response modifier (BRM) that has been used as an adjuvant therapy for cancer since 1980, mostly in ...
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Contribution of Biocatalysis to the Synthesis of β-(1,3)-Glucans

Pp. 102-111 (10)

Vincent Ferrières, Laurent Legentil, Balla Sylla, Karine Descroix, Caroline Nugier-Chauvin and Richard Daniellou

Abstract

The lightning progress in the understanding of enzymatic mechanisms, democratization of molecular biology tools and their introduction in chemistry laboratories, the pressure of green chemistry notions leading to the need for alternative sustainable and more environmentally friendly approaches, and probably economic factors as well, all these parameters allowed the development of new synthetic strategies based on biocatalysis. This chapter is dedicated to the use of glucosyl hydrolases and some of their mutants, i.e., glucosynthases and thioligases, to the preparation of β-(1,3)-(thio)glucosides.

Keywords:

Glucan, thio, oligo, synthesis, donor, residue, biocatalysis, conjugate, branching, laminarin, residue, biocatalyst, thioglycosides, strategy, carbohydrate, NMR, glycans, transferase, enzymes, laminarin.

Affiliation:

Ecole Nationale Supérieure de Chimie de Rennes, CNRS, UMR 6226, Avenue du Général Leclerc, CS 50837, 35708 Rennes Cedex 7, France