Chemical Synthesis of Oligo-(1→3)-β-D-Glucans
Pp. 83-101 (19)
Vincent Ferrières, Laurent Legentil, Balla Sylla, Karine Descroix, Caroline Nugier-Chauvin and Richard Daniellou
The synthesis of β-(1→3)-glucans is at present has more than a chemical
challenge. The discovery of their biological properties found development for new anticancer
therapies, the efficient preparation of pure and structurally well-defined
β-(1→3)-glucans has generated interest in the glycochemist community. This chapter
highlights recent strategies that not only yielded the target biomolecules but have also
drawn attention on basic limitations. It also shows how it is possible to strengthen the
activity of β-glucans by conjugation to non saccharidic derivatives.
Glucan, synthesis, natural, biopolymer, CR3, cancer, Dectin-1, linear,
donor, chemical, analog, strategy, BRM, oligo, reduction, oxygen, carbonyl,
oligomer, natural, position.
Ecole Nationale Supérieure de Chimie de Rennes, CNRS, UMR 6226, Avenue du Général Leclerc, CS 50837, 35708 Rennes Cedex 7, France