Biology and Chemistry of Beta Glucan Volume Title: Beta-Glucan, Structure, Chemistry and Specific Application

Indexed in: EBSCO, Ulrich's Periodicals Directory

β-Glucan is generally considered to be a very safe immunomodulator. It is a well-known biological response modifier (BRM) that has been used as an adjuvant therapy for cancer since 1980, mostly in ...
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Chemical Synthesis of Oligo-(1→3)-β-D-Glucans

Pp. 83-101 (19)

Vincent Ferrières, Laurent Legentil, Balla Sylla, Karine Descroix, Caroline Nugier-Chauvin and Richard Daniellou

Abstract

The synthesis of β-(1→3)-glucans is at present has more than a chemical challenge. The discovery of their biological properties found development for new anticancer therapies, the efficient preparation of pure and structurally well-defined β-(1→3)-glucans has generated interest in the glycochemist community. This chapter highlights recent strategies that not only yielded the target biomolecules but have also drawn attention on basic limitations. It also shows how it is possible to strengthen the activity of β-glucans by conjugation to non saccharidic derivatives.

Keywords:

Glucan, synthesis, natural, biopolymer, CR3, cancer, Dectin-1, linear, donor, chemical, analog, strategy, BRM, oligo, reduction, oxygen, carbonyl, oligomer, natural, position.

Affiliation:

Ecole Nationale Supérieure de Chimie de Rennes, CNRS, UMR 6226, Avenue du Général Leclerc, CS 50837, 35708 Rennes Cedex 7, France