Supercritical fluid particle design (SCF PD) offers a number of routes to improve solubility and dissolution rate for enhancing
the bioavailability of poorly water-soluble drugs, which can be adopted through an in-depth knowledge of SCF PD processes and the molecular
properties of active pharmaceutical ingredients (API) and drug delivery system (DDS). Combining with research experiences in
our laboratory, this review focuses on the most recent development of different routes (nano-micron particles, polymorphic particles,
composite particles and bio-drug particles) to improve solubility and dissolution rate of poorly water-soluble drugs, covering the fundamental
concept of SCF and the principle of SCF PD processes which are typically used to control particle size, shape, morphology and
particle form and hence enable notable improvement in the dissolution rate of the poorly water-soluble drugs. The progress of the industrialization
of SCF PD processes in pharmaceutical manufacturing environment with scaled-up plant under current good manufacturing
process (GMP) specification is also considered in this review.
Keywords: Supercritical fluid particle design, poorly water-soluble drugs, solubility, dissolution, nano-micron particles, polymorphic particles,
composite particles, bio-drug particles.
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