Delivery of Poorly Soluble Compounds by Amorphous Solid Dispersions

Author(s): Thomas W.Y. Lee, Nathan A. Boersen, H.W. Hui, S.F. Chow, K.Y. Wan, Albert H.L. Chow.

Journal Name: Current Pharmaceutical Design

Volume 20 , Issue 3 , 2014

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Abstract:

Solid state manipulation by amorphous solid dispersion has been the subject of intensive research for decades due to their excellent potential for dissolution and bioavailability enhancement. The present review aims to highlight the latest advancement in this area, with focus on the fundamentals, characterization, formulation development and manufacturing of amorphous solid dispersions as well as the new generation amorphization technologies. Additionally, specific applications of amorphous solid dispersion in the formulation of herbal drugs or bioactive natural products are reviewed to reflect the growing interest in this relatively neglected area.

Keywords: Amorphous solid dispersion, polymer carrier, glass transition, molecular mobility, physical stability, amorphization technologies.

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Article Details

VOLUME: 20
ISSUE: 3
Year: 2014
Page: [303 - 324]
Pages: 22
DOI: 10.2174/13816128113199990396
Price: $58

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