Solid state manipulation by amorphous solid dispersion has been the subject of intensive research for decades due to their excellent
potential for dissolution and bioavailability enhancement. The present review aims to highlight the latest advancement in this area,
with focus on the fundamentals, characterization, formulation development and manufacturing of amorphous solid dispersions as well as
the new generation amorphization technologies. Additionally, specific applications of amorphous solid dispersion in the formulation of
herbal drugs or bioactive natural products are reviewed to reflect the growing interest in this relatively neglected area.
Keywords: Amorphous solid dispersion, polymer carrier, glass transition, molecular mobility, physical stability, amorphization technologies.
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