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Current Nanoscience
ISSN (Print): 1573-4137
ISSN (Online): 1875-6786
VOLUME: 10
ISSUE: 2
DOI: 10.2174/15734137113099990055      Price:  $58









Spectral Features and In Vitro Antioxidant Study of Nanoscale Solid Dispersions of Different Sizes of Coenzyme Q10 (CoQ10) Prepared by Heat Melt and High-pressure Homogenization Method

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Author(s): Yunlong Ge, Xiuhua Zhao, Song Wang, Yuangang Zu, Qingyong Li, Mei Sang, Xiaoyu Sui and Kunlun Wang
Pages 292-296 (5)
Abstract:
Coenzyme Q10 (CoQ10) has been reported as a powerful antioxidant in plasma. Recent in vivo investigations showed that cosmetically applied CoQ10 can reduce photo-aging. However, CoQ10 was barely satisfactory in topical drug delivery because of its poor solubility and high molecular weight. To improve the anti-oxidative efficiency of CoQ10 in skin photo-aging, a novel water-soluble nanoscale solid dispersion of CoQ10 (CoQ10-SD) was prepared by heat melt and high-pressure homogenization method in the present study. Three sizes of CoQ10-SDs were obtained and characterized. The spectral investigations showed that the smaller particle size solution of CoQ10-SD was more effective against ultraviolet (UV) radiation. The UVB radiation absorption and reflection of the CoQ10-SD solution increased with increasing concentration and decreasing particle size. The in vitro antioxidants of CoQ10-SD were also assessed. The results showed that, smaller particle size results in higher antioxidant effect. A lower level of intracellular reactive oxygen species was found when the myocardial cells were treated with CoQ10-SD of smaller size. These ndings indicated that CoQ10-SD can be an effective cosmetic delivery system to protect the skin from early aging induced by UV.
Keywords:
Antioxidant study, coenzyme Q10, nanoparticles, solid dispersion, UV protective.
Affiliation:
Key Laboratory of Forest Plant Ecology, Northeast Forestry University, Ministry of Education, Harbin, Heilongjiang 150040, China.