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Current Nanoscience
ISSN (Print): 1573-4137
ISSN (Online): 1875-6786
DOI: 10.2174/15734137113099990055      Price:  $58

Spectral Features and In Vitro Antioxidant Study of Nanoscale Solid Dispersions of Different Sizes of Coenzyme Q10 (CoQ10) Prepared by Heat Melt and High-pressure Homogenization Method

Author(s): Yunlong Ge, Xiuhua Zhao, Song Wang, Yuangang Zu, Qingyong Li, Mei Sang, Xiaoyu Sui and Kunlun Wang
Pages 292-296 (5)
Coenzyme Q10 (CoQ10) has been reported as a powerful antioxidant in plasma. Recent in vivo investigations showed that cosmetically applied CoQ10 can reduce photo-aging. However, CoQ10 was barely satisfactory in topical drug delivery because of its poor solubility and high molecular weight. To improve the anti-oxidative efficiency of CoQ10 in skin photo-aging, a novel water-soluble nanoscale solid dispersion of CoQ10 (CoQ10-SD) was prepared by heat melt and high-pressure homogenization method in the present study. Three sizes of CoQ10-SDs were obtained and characterized. The spectral investigations showed that the smaller particle size solution of CoQ10-SD was more effective against ultraviolet (UV) radiation. The UVB radiation absorption and reflection of the CoQ10-SD solution increased with increasing concentration and decreasing particle size. The in vitro antioxidants of CoQ10-SD were also assessed. The results showed that, smaller particle size results in higher antioxidant effect. A lower level of intracellular reactive oxygen species was found when the myocardial cells were treated with CoQ10-SD of smaller size. These ndings indicated that CoQ10-SD can be an effective cosmetic delivery system to protect the skin from early aging induced by UV.
Antioxidant study, coenzyme Q10, nanoparticles, solid dispersion, UV protective.
Key Laboratory of Forest Plant Ecology, Northeast Forestry University, Ministry of Education, Harbin, Heilongjiang 150040, China.