Weakly Stable Regions and Protein-Protein Interactions in Beta-Barrel Membrane Proteins

Author(s): Hammad Naveed, Jie Liang.

Journal Name: Current Pharmaceutical Design

Volume 20 , Issue 8 , 2014

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We briefly discuss recent progress in computational characterization of the sequence and structural properties of β-barrel membrane properties. We discuss the emerging concept of weakly stable regions in β-barrel membrane proteins, computational methods to identify these regions and mechanisms adopted by β-barrel membrane proteins in nature to stabilize them. We further discuss computational methods to identify protein-protein interactions in β-barrel membrane proteins and recent experimental studies that aim at altering the biophysical properties including oligomerization state and stability of β-barrel membrane proteins based on the emerging organization principles of these proteins from recent computational studies.

Keywords: β-barrel membrane proteins — protein-protein interaction — weakly stable regions— VDAC — Tom40— OmpF.

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Article Details

Year: 2014
Page: [1268 - 1273]
Pages: 6
DOI: 10.2174/13816128113199990071
Price: $58

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PDF: 17