We briefly discuss recent progress in computational characterization of the sequence and structural properties of β-barrel
membrane properties. We discuss the emerging concept of weakly stable regions in β-barrel membrane proteins, computational methods
to identify these regions and mechanisms adopted by β-barrel membrane proteins in nature to stabilize them. We further discuss computational
methods to identify protein-protein interactions in β-barrel membrane proteins and recent experimental studies that aim at altering
the biophysical properties including oligomerization state and stability of β-barrel membrane proteins based on the emerging organization
principles of these proteins from recent computational studies.
Keywords: β-barrel membrane proteins — protein-protein interaction — weakly stable regions— VDAC — Tom40— OmpF.
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