The aim of this work was to investigate the antibacterial activity of clove (Syzygium aromaticum) essential oil
against multidrug resistant clinical strains of Klebsiella pneumoniae ESBL+. Materials: The antibacterial activity of the
oil was tested against standard strain Klebsiella pneumoniae ATCC 700603 and 60 clinical strains of Klebsiella pneumoniae
isolated from patients with infections of the respiratory tract, abdominal cavity, urinary tract, skin and from the hospital
environment. Methods: The agar dilution method was used to assess the inhibition of microbial growth at various
concentrations of the clove oil. Susceptibility testing to antibiotics was carried out using disc-diffusion. Results: The results
of experiments showed that clove essential oil possessed very strong activity against all of the clinical strains of extendedspectrum
β-lactamase (ESBL)-producing ESBL+ from Klebsiella pneumoniae. Conclusions: The results of this study suggest
the potential use of clove essential oil against K. pneumoniae ESBL+ that is responsible for infections difficult to
treat. Essential oils my be an excellent alternative for synthetic preparations and, used in combination with antibiotics,
may prevent antibiotic-resistant strain development.
Keywords: Clove essential oil, ESBL+, K. pneumoniae, Minimal Inhibitory Concentration.
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