Abstract
The interaction between Cryptococcus neoformans and the host system is a consummate process, on account of the multiple components involved in its traversal of the blood-brain barrier (BBB). It is possible that this yeast pathogen may use different mechanisms of invasion under different physiological or pathological conditions. Understanding these mechanisms of encroachment can explicate the route of invasion, which may provide us with an indication for identifying the potential drug target sites. Current C. neoformans management still relies on the anti-fungal reagents, such as amphotericin B, fluconazole, or fluorocytosine. However, potential treatments on BBB, e.g., flurofamide and simvastatin, are emerging. This review summarizes the possible routes for C. neoformans traversal of the BBB, current regimens for C. neoformans, and potential new targets for treatments.
Keywords: Amphotericin B, brain invasion, blood-brain barrier, C. neoformans, lipid rafts, simvasatatin.
Anti-Infective Agents
Title:The Blood-Brain Barrier: Targeting in the Pathogenesis of C. neoformans Meningitis and Drug Discovery
Volume: 11 Issue: 2
Author(s): Hsiang-Kuang Tseng, Sheng-He Huang, Gregory Shackleford and Ambrose Jong
Affiliation:
Keywords: Amphotericin B, brain invasion, blood-brain barrier, C. neoformans, lipid rafts, simvasatatin.
Abstract: The interaction between Cryptococcus neoformans and the host system is a consummate process, on account of the multiple components involved in its traversal of the blood-brain barrier (BBB). It is possible that this yeast pathogen may use different mechanisms of invasion under different physiological or pathological conditions. Understanding these mechanisms of encroachment can explicate the route of invasion, which may provide us with an indication for identifying the potential drug target sites. Current C. neoformans management still relies on the anti-fungal reagents, such as amphotericin B, fluconazole, or fluorocytosine. However, potential treatments on BBB, e.g., flurofamide and simvastatin, are emerging. This review summarizes the possible routes for C. neoformans traversal of the BBB, current regimens for C. neoformans, and potential new targets for treatments.
Export Options
About this article
Cite this article as:
Tseng Hsiang-Kuang, Huang Sheng-He, Shackleford Gregory and Jong Ambrose, The Blood-Brain Barrier: Targeting in the Pathogenesis of C. neoformans Meningitis and Drug Discovery, Anti-Infective Agents 2013; 11 (2) . https://dx.doi.org/10.2174/2211352511311020005
DOI https://dx.doi.org/10.2174/2211352511311020005 |
Print ISSN 2211-3525 |
Publisher Name Bentham Science Publisher |
Online ISSN 2211-3533 |
Call for Papers in Thematic Issues
An Overview of Drugs for Multiple Targets and Variants of SARS-CoV-2 Through Artificial Intelligence, Machine Learning, Deep Learning, and Experimental Analysis
The emergence and rapid evolution of SARS-CoV-2 variants have posed significant challenges in the ongoing fight against the COVID-19 pandemic. The development of effective treatments for multiple viral targets and variants demands innovative approaches, including artificial intelligence (AI), machine learning (ML), and deep learning (DL) techniques. This special issue aims ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Recent Advances in the Development of Anti-Infective Prophylactic and/or Therapeutic Agents Based on Toll-Like Receptor (TLRs)
Recent Patents on Anti-Infective Drug Discovery Recent Progress on Antifungal Drug Development
Current Pharmaceutical Biotechnology Target Based Drug Design - A Reality in Virtual Sphere
Current Medicinal Chemistry Fluoroquinolones: Blessings Or Curses
Current Drug Targets Nanomedicine in Therapeutic Intervention of Tuberculosis Meningitis
Current Nanoscience Tuberculosis Detection from Chest Radiographs: A Comprehensive Survey on Computer-Aided Diagnosis Techniques
Current Medical Imaging Transport Mechanisms at the Blood-Cerebrospinal-Fluid Barrier: Role of Megalin (LRP2)
Recent Patents on Endocrine, Metabolic & Immune Drug Discovery The NK-1 Receptor: A New Target in Cancer Therapy
Current Drug Targets Preliminary Anti-Coxsackie Activity of Novel 1-[4-(5,6-dimethyl(H)- 1H(2H)-benzotriazol-1(2)-yl)phenyl]-3-alkyl(aryl)ureas
Medicinal Chemistry CGRP-Receptor Antagonism in Migraine Treatment
CNS & Neurological Disorders - Drug Targets TargetingQuorum Sensing and Competence Stimulation for Antimicrobial Chemotherapy
Current Drug Targets Murine Skin-resident γδT Cells Impair the Immune Response to HSV in Skin
Infectious Disorders - Drug Targets Coagulation and Sepsis
Endocrine, Metabolic & Immune Disorders - Drug Targets Inhibition of Virulence Factors and Biofilm Formation of <i>Acinetobacter Baumannii</i> by Naturally-derived and Synthetic Drugs
Current Drug Targets Extrapulmonary Tuberculosis- Its Management and Control
Current Drug Therapy The Injured Cochlea as a Target for Inflammatory Processes, Initiation of Cell Death Pathways and Application of Related Otoprotective Strategies
Recent Patents on CNS Drug Discovery (Discontinued) Metabolite Quantification in Tumours by Magnetic Resonance Spectroscopy: Objectives, Results and Perspectives
Current Medical Imaging Rho as a Target to Promote Repair: Translation to Clinical Studies with Cethrin
Current Pharmaceutical Design Targeting the Nucleus: An Overview of Auger-Electron Radionuclide Therapy
Current Drug Discovery Technologies New Progress in Azole Compounds as Antimicrobial Agents
Mini-Reviews in Medicinal Chemistry