Title:Cu(II) Schiff Base Complex as a Highly Efficient Catalyst for the Synthesis of Polyhydroquinoline Derivatives via Hantzsch Condensation in Water
VOLUME: 16 ISSUE: 10
Author(s):Seyed Mohammad Vahdat
Affiliation:Department of Chemistry, Ayatollah Amoli Branch, Islamic Azad University, Amol, Iran.
Keywords:Cu(II) schiff-base catalyst, hantzsch condensation, polyhydroquinoline, water solvent.
Abstract:In the present study, Cu(II) Schiff-base complex is introduced as a highly efficient and green solid catalyst for
the unsymmetrical Hantzsch condensation through a four-component coupling of various aldehydes, dimedone, ethyl
acetoacetate and ammonium acetate to form polyhydroquinoline derivatives in good to excellent yields. This reaction was
carried out in the presence of 1 mol% of catalysts in water at room temperature. The reusability of the catalysts was
demonstrated by a five-run test. Remarkable features of this new procedure are cleaner reaction profiles, shorter
reactiontimes, simple experimental and work-up procedures.
