There are a number of atopic conditions that involve mast cells ranging from common allergies to arthritis and chronic pelvic
pain syndrome. In addition to the well known allergic triggers, many food substances, drugs, as well as physical and mental stressful conditions
could trigger mast cell activation in the absence of any allergic diathesis. The chronicity and morbidity of these conditions and the
concern for the “adverse side effects” of the available therapeutic agents has prompted the widespread use of complementary and alternative
medicines (CAM). One of the most common CAM interventions in the treatment of allergies is the use of dietary supplements
that may contain specific compounds such as chondroitin sulfate, bioflavonoids or various herb extracts including Forsythia, Gingko, and
Echinacea. The basis of such use has evolved from clinical anecdotal observations over time, to a growing number of in vitro and some in
vivo studies that support the use of some of these compounds, especially select flavonoids.
Keywords: Herbal products, flavonoids, chondroitin, luteolin, olive kernel oil, quercetin.
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