psyllium, a medicinally active gel forming natural polysaccharide and a dietary fiber has been used as a medicine
in myriad of conditions such as constipation and inflammatory bowel syndrome. One of its more recent uses that
have received attention has been its ability to reduce blood sugar levels in diabetics. Therefore present work is an attempt
to formulate anti diabetic drug Metformin as a controlled release floating delivery making use of pysllium as release
retardant and to assist the drug in stabilizing blood sugar level in type II diabetics. Drug and excipients compatibility
studies were monitored by thermal analysis using differential scanning calorimeter (DSC) and Fourier transform infra red
(FTIR). The DSC thermogram and FTIR of drug and drug-polymer mixture did not reveal any incompatibility. psyllium
was tried in different concentrations along with other polymers like HPMC K15M and carbopol 940 to achieve the desired
release profile. The total drug: polymer ratio was kept between 1:0.4 to 1:0.5, and different polymer combinations were
tried to achieve desired drug release for 12 hours. The prepared tablets were evaluated for in vitro release studies and
floating behavior. Our conclusion from the present study indicated that pysllium could potentially be used in conjunction
with other polymers to formulate controlled release formulations of anti-diabetic drugs to provide better control over
blood glucose levels.
Keywords: psyllium, Metformin hydrochloride, Floating drug delivery.
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