The aim of the present work was to develop colon specific drug delivery system for ibuprofen using natural
polymers as carriers. We have investigated colon specific, pulsatile device to achieve time and site specific release of ibuprofen
based on chronopharmaceutical considerations. The basic design consists of an insoluble hard gelatin capsule
body, filled with ibuprofen surface solid dispersions and sealed with guar gum hydrogel plug. The entire capsule was
coated with ethyl cellulose, so that the variability in gastric emptying time can be overcome and a colon specific release
can be achieved. Surface solid dispersions (SSDs) of ibuprofen were prepared using natural polymers such as Guar gum
(GG), Hupu gum (HG) and Xanthan gum (XG) in the weight ratios of 1:0.5, 1:1 and 1:2 by using solvent evaporation
method. Physicochemical properties of the prepared SSD were characterized by FTIR and DSC. Optimized SSD were obtained
by practical yield, drug content, solubility and dissolution studies and were selected for further fabrication of pulsincaps.
Guar gum was used as hydrogel plug material to maintain a suitable lag period. The prepared pulsincaps were
evaluated for in-vitro release. Pulsincap formulated with Ibuprofen-Hupu gum (PF3) at 1:2 ratio of surface solid dispersions
showed highest drug release over the period of 12 hr and release was found to be Higuchi model kinetics. The present
research study results have confirmed that the modified pulsincap of ibuprofen is a suitable device for the time dependent
and site specific delivery to the colon segment of GIT.
Keywords: Surface solid dispersions, chronotheraphy, hydrogel plug, guar gum, hupu gum, pulsincap.
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