Preparation of a Molecularly Imprinted Soft Contact Lens as a New Ocular Drug Delivery System for Dorzolamide

Bizhan Malaekeh-      Nikouei; Seyedeh Atefeh      Vahabzadeh; Seyed Ahmad      Mohajeri

Abstract

In the present work a series of imprinted (MIPs) and non-imprinted (NIPs) hydrogels were prepared using 2-hydroxyethyl methacrylate (HEMA) as a backbone monomer, ethylene glycol dimethacrylate (EGDMA) as a cross-linker monomer, methacrylic acid (MAA) as a functional monomer and dorzolamide (DZD) as the template molecule. Different concentrations of MAA (0, 100, 200, 400 mM) were used for preparation of NIPs. Two DZD: MAA molar ratios (1:8 and 1:4) and 400 mM MAA were also applied in imprinting process. The hydrogels (0.4 mm thickness) were synthesized by thermal polymerization at 50°C in 24h in a polypropylene mould. Then, the swelling and binding properties of hydrogels were evaluated in water. Their loading and releasing properties were also studied in NaCl 0.9% and artificial lachrymal fluid. The results showed that using MAA as co-monomer and applying molecular imprinting technique increased loading capacity of hydrogels. The optimized imprinted hydrogel (MIP1:4), prepared with 400 mM MAA and DZD: MAA molar ratio of 1:4, had the highest affinity for DZD and the greatest ability to control the release process in aqueous media. Our data indicated that the use of suitable co-monomer and applying a molecular imprinting technique had important influence on loading and releasing properties of hydrogels.

Keywords: Molecular imprinting, ocular drug delivery systems, soft contact lenses, controlled release, dorzolamide.

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Current Drug Delivery

Title:Preparation of a Molecularly Imprinted Soft Contact Lens as a New Ocular Drug Delivery System for Dorzolamide

Volume: 10 Issue: 3

Author(s): Bizhan Malaekeh- Nikouei, Seyedeh Atefeh Vahabzadeh and Seyed Ahmad Mohajeri

Affiliation:

Keywords: Molecular imprinting, ocular drug delivery systems, soft contact lenses, controlled release, dorzolamide.

Abstract: In the present work a series of imprinted (MIPs) and non-imprinted (NIPs) hydrogels were prepared using 2-hydroxyethyl methacrylate (HEMA) as a backbone monomer, ethylene glycol dimethacrylate (EGDMA) as a cross-linker monomer, methacrylic acid (MAA) as a functional monomer and dorzolamide (DZD) as the template molecule. Different concentrations of MAA (0, 100, 200, 400 mM) were used for preparation of NIPs. Two DZD: MAA molar ratios (1:8 and 1:4) and 400 mM MAA were also applied in imprinting process. The hydrogels (0.4 mm thickness) were synthesized by thermal polymerization at 50°C in 24h in a polypropylene mould. Then, the swelling and binding properties of hydrogels were evaluated in water. Their loading and releasing properties were also studied in NaCl 0.9% and artificial lachrymal fluid. The results showed that using MAA as co-monomer and applying molecular imprinting technique increased loading capacity of hydrogels. The optimized imprinted hydrogel (MIP1:4), prepared with 400 mM MAA and DZD: MAA molar ratio of 1:4, had the highest affinity for DZD and the greatest ability to control the release process in aqueous media. Our data indicated that the use of suitable co-monomer and applying a molecular imprinting technique had important influence on loading and releasing properties of hydrogels.

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Nikouei Bizhan Malaekeh-, Vahabzadeh Seyedeh Atefeh and Mohajeri Seyed Ahmad, Preparation of a Molecularly Imprinted Soft Contact Lens as a New Ocular Drug Delivery System for Dorzolamide, Current Drug Delivery 2013; 10 (3) . https://dx.doi.org/10.2174/1567201811310030004

DOI https://dx.doi.org/10.2174/1567201811310030004	Print ISSN 1567-2018
Publisher Name Bentham Science Publisher	Online ISSN 1875-5704

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