Background: Retention and compliance are hurdles in many clinical trials designed for adolescents. Factors that
may improve these issues in a challenging population may lead to increased data and power in much needed adolescent
substance abuse research.
Methods: Within a large-scale smoking cessation study for adolescents, physician continuity (PC) was examined to determine
its effect on retention, compliance, and cessation.
Results: In an analysis of 98 participants, participants with physician continuity throughout the study were more likely to
attend more treatment visits and be medication compliant. It was also found that PC had no effect on participant smoking
Conclusions: It appears that PC may be one way to increase retention and compliance within an adolescent clinical trial,
without interfering with the specific aim of the research study (in this case, smoking cessation).