Current Molecular Medicine

David W. Li  
College of Medicine
University of Nebraska Medical Center
Omaha, NE
USA

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Human Progenitor Cells for Bone Engineering Applications

Author(s): G.M. de Peppo, P. Thomsen, C. Karlsson, R. Strehl, A. Lindahl, J. Hyllner.

Abstract:

In this report, the authors review the human skeleton and the increasing burden of bone deficiencies, the limitations encountered with the current treatments and the opportunities provided by the emerging field of cell-based bone engineering. Special emphasis is placed on different sources of human progenitor cells, as well as their pros and cons in relation to their utilization for the large-scale construction of functional bone-engineered substitutes for clinical applications. It is concluded that, human pluripotent stem cells represent a valuable source for the derivation of progenitor cells, which combine the advantages of both embryonic and adult stem cells, and indeed display high potential for the construction of functional substitutes for bone replacement therapies.

Keywords: Adult stem cells, bone deficiencies, bone engineering, embryonic-derived progenitors, human embryonic stem cells, human skeleton, mesenchymal stem cells.

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Article Details

VOLUME: 13
ISSUE: 5
Year: 2013
Page: [723 - 734]
Pages: 12
DOI: 10.2174/1566524011313050004
Price: $58