Prostaglandins Pathway as a Possible Biological Link Between Cancer and Major Depression
Maria Luca, Antonina Luca, Agata Celia and Carmela Calandra
Affiliation: Department of Medical and Surgery Specialties, Psychiatry Unit of the University Hospital “Policlinico- Vittorio Emanuele” of Catania (Sicily), Italy. Via S. Sofia 78 95100 Catania.
Prostaglandins (PGs) are bioactive lipids involved in many physiological functions as well as in inflammation.
The overexpression of PGs is a critical common point in the pathophysiology of cancer and depression: high plasmatic
levels of these bioactive lipids have been reported in both disorders. In this review, the authors would like to deepen the
role of PGs in cancer and depression, in order to make inquiries about a possible biological link (via the PGs pathway)
between the two disorders, debating also over the implications of such a link in the therapeutic field.
Keywords: bioactive lipids, biological link, cancer, depression, prostaglandins, therapeutic implications.
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