Current Angiogenesis

Guo-Chang Fan , PHD
Dept. of Pharmacology and Cell Biophysics
University of Cincinnati College of Medicine


Prostaglandins Pathway as a Possible Biological Link Between Cancer and Major Depression

Author(s): Maria Luca, Antonina Luca, Agata Celia and Carmela Calandra

Affiliation: Department of Medical and Surgery Specialties, Psychiatry Unit of the University Hospital “Policlinico- Vittorio Emanuele” of Catania (Sicily), Italy. Via S. Sofia 78 95100 Catania.


Prostaglandins (PGs) are bioactive lipids involved in many physiological functions as well as in inflammation. The overexpression of PGs is a critical common point in the pathophysiology of cancer and depression: high plasmatic levels of these bioactive lipids have been reported in both disorders. In this review, the authors would like to deepen the role of PGs in cancer and depression, in order to make inquiries about a possible biological link (via the PGs pathway) between the two disorders, debating also over the implications of such a link in the therapeutic field.

Keywords: bioactive lipids, biological link, cancer, depression, prostaglandins, therapeutic implications.

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Article Details

Page: [143 - 148]
Pages: 6
DOI: 10.2174/2211552802999140131105925