Leptin-Induced Endothelial Dysfunction: A Target for Therapeutic Interventions

Author(s): Gregory A. Payne , Johnathan D. Tune , Jarrod D. Knudson .

Journal Name: Current Pharmaceutical Design

Volume 20 , Issue 4 , 2014

Abstract:

Leptin has received much attention since its cloning in 1994. Initially, leptin research centered on satiety, energy balance and sympathetic activation. However, hyperleptinemia has since been identified as an independent risk factor for various cardiovascular pathologies including atherosclerotic coronary artery disease. Over the last decade, multiple studies have implicated leptin as an important mediator in endothelial dysfunction and neointimal hyperplasia, both key steps in the evolution of atherosclerotic vascular changes. Additionally, more recent evidence indicates that paracrine leptin release from perivascular adipose tissue (PVAT) has deleterious effects on the underlying endothelium and vascular smooth muscle cells (SMC), including the coronary circulation. This report reviews pertinent literature on leptin-mediated endothelial dysfunction, SMC proliferation and the role of PVAT-derived leptin with an emphasis on the coronary circulation and discussions of currently proposed molecular mechanisms of PVAT-mediated coronary endothelial dysfunction and neointimal hyperplasia.

Keywords: Leptin, endothelium, endothelial dysfunction, perivascular adipose tissue, cardiovascular disease, metabolic syndrome.

Rights & PermissionsPrintExport Cite as

Article Details

VOLUME: 20
ISSUE: 4
Year: 2014
Page: [603 - 608]
Pages: 6
DOI: 10.2174/13816128113199990017
Price: $58

Article Metrics

PDF: 19