Solvent-Free Synthesis of 4,5-Dihydropyrano[c]chromene Derivatives Over TiO2 Nanoparticles as an Economical and Efficient Catalyst
Titanium dioxide nanoparticles (TiO2 NPs) were used as an effective catalyst in the solvent-free, one-pot threecomponent
reaction of aromatic aldehydes, malononitrile and 4-hydroxycoumarin to produce corresponding dihydropyrano[
c]chromenes in high yields. This method has the advantages of a simple operation, short reaction time, high yields,
easy work-up, reusability of the catalyst, and an environmentally friendly specificity.
Keywords: Dihydropyrano[c]chromenes, Domino Knoevenagel-Michael addition, Solvent-free, TiO2 nanoparticles.
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