Mini-Review: Polyamines Metabolism, Toxicity and Potent Therapeutical Use
Lamia Djouhri-Bouktab, Jean M. Rolain and Jean M. Brunel
Affiliation: Centre de Recherche en Cancérologie de Marseille (CRCM), CNRS, UMR7258; Institut Paoli Calmettes; Aix-Marseille Université, UM 105; Inserm, U1068, F-13009, Marseille, France.
In recent years, extensive researches have emphasized the fact that polyamines conjugates acting as possessing
antitumor, antimicrobial candidates are becoming important in the biogical and medicinal field. In this review, a general
design strategy of polyamine conjugates as well as recent progress in both fundamental mechanism studies and potent
therapeutic use as anti infectious agents are provided for the readers.
Keywords: Anticancer activity, antimicrobial activity, metabolism, polyamines, therapeutical use.
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