Mini-Review: Polyamines Metabolism, Toxicity and Potent Therapeutical Use
Lamia Djouhri-Bouktab, Jean M. Rolain and Jean M. Brunel
Affiliation: Centre de Recherche en Cancérologie de Marseille (CRCM), CNRS, UMR7258; Institut Paoli Calmettes; Aix-Marseille Université, UM 105; Inserm, U1068, F-13009, Marseille, France.
Keywords: Anticancer activity, antimicrobial activity, metabolism, polyamines, therapeutical use.
In recent years, extensive researches have emphasized the fact that polyamines conjugates acting as possessing
antitumor, antimicrobial candidates are becoming important in the biogical and medicinal field. In this review, a general
design strategy of polyamine conjugates as well as recent progress in both fundamental mechanism studies and potent
therapeutic use as anti infectious agents are provided for the readers.
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