Anti-Infective Agents

Anti-Infective Agents in Medicinal Chemistry

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Mini-Review: Polyamines Metabolism, Toxicity and Potent Therapeutical Use

Author(s): Lamia Djouhri-Bouktab, Jean M. Rolain and Jean M. Brunel

Affiliation: Centre de Recherche en Cancérologie de Marseille (CRCM), CNRS, UMR7258; Institut Paoli Calmettes; Aix-Marseille Université, UM 105; Inserm, U1068, F-13009, Marseille, France.

Keywords: Anticancer activity, antimicrobial activity, metabolism, polyamines, therapeutical use.

Abstract:

In recent years, extensive researches have emphasized the fact that polyamines conjugates acting as possessing antitumor, antimicrobial candidates are becoming important in the biogical and medicinal field. In this review, a general design strategy of polyamine conjugates as well as recent progress in both fundamental mechanism studies and potent therapeutic use as anti infectious agents are provided for the readers.

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Article Details

VOLUME: 12
ISSUE: 1
Page: [95 - 103]
Pages: 9
DOI: 10.2174/22113525113119990118