Bacterial Fatty Acid Synthesis: Effect of Tween 80 on Antibiotic Potency Against Streptococcus Agalactiae and Methicillin-Resistant Staphylococcus Aureus
Dragan Krsta, Caron Ku, Ian T. Crosby, Ben Capuano and David T. Manallack
Affiliation: Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University (Parkville Campus), 381 Royal Parade, Parkville, VIC 3052, Australia.
The effect of varying concentrations of Tween 80 on the antimicrobial potency of platensimycin and triclosan
was investigated using both Streptococcus agalactiae (S. agalactiae) and methicillin-resistant Staphylococcus aureus
(MRSA). In the presence of very low concentrations of Tween 80 (0.02%) both platensimycin and triclosan were rendered
ineffective against S. agalactiae. A linear concentration-dependence was found with the antimicrobial activity of triclosan
against MRSA showing a loss in effectiveness with increasing concentrations of Tween 80. Platensimycin, on the other
hand, demonstrated improved antibiotic activity at higher concentrations of Tween 80. The differential effects of these
two agents have implications for the regulation of lipids in Gram positive organisms and the viability of bacterial fatty
acid synthesis inhibitors as antibiotics.
Keywords: Fatty acids, linezolid, methicillin-resistant Staphylococcus aureus, platensimycin, Streptococcus agalactiae, triclosan,
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