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Anti-Infective Agents

Editor-in-Chief

ISSN (Print): 2211-3525
ISSN (Online): 2211-3533

Non-Genotoxic Assessment of a Natural Antimicrobial Agent: Squalamine

Author(s): Kamel Alhanout, Carole D. Giorgio, Michel D. Meo and Jean M. Brunel

Volume 12, Issue 1, 2014

Page: [75 - 79] Pages: 5

DOI: 10.2174/22113525113119990114

Price: $65

Abstract

Squalamine, a natural aminosterol compound isolated from the dogfish shark Squalus acanthias, is reported to possess high antimicrobial activities. Herein, we assessed its in vitro genotoxic properties by using the Ames test and the micronucleus assay. All the experimental results demonstrate that squalamine is a non genotoxic molecule and call for further work to evaluate its potent human therapeutic use as a new class of antinfectious agents.

Keywords: Ames test, antimicrobial agent, non-genotoxic, squalamine.


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