Anti-Infective Agents

Anti-Infective Agents in Medicinal Chemistry

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Non-Genotoxic Assessment of a Natural Antimicrobial Agent: Squalamine

Author(s): Kamel Alhanout, Carole D. Giorgio, Michel D. Meo and Jean M. Brunel

Affiliation: Centre de Recherche en Cancerologie de Marseille (CRCM), CNRS, UMR7258; Institut Paoli Calmettes; Aix-Marseille Universite, UM 105; Inserm, U1068, F-13009, Marseille, France.

Keywords: Ames test, antimicrobial agent, non-genotoxic, squalamine.

Abstract:

Squalamine, a natural aminosterol compound isolated from the dogfish shark Squalus acanthias, is reported to possess high antimicrobial activities. Herein, we assessed its in vitro genotoxic properties by using the Ames test and the micronucleus assay. All the experimental results demonstrate that squalamine is a non genotoxic molecule and call for further work to evaluate its potent human therapeutic use as a new class of antinfectious agents.

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Article Details

VOLUME: 12
ISSUE: 1
Page: [75 - 79]
Pages: 5
DOI: 10.2174/22113525113119990114