Non-Genotoxic Assessment of a Natural Antimicrobial Agent: Squalamine
Kamel Alhanout, Carole D. Giorgio, Michel D. Meo and Jean M. Brunel
Affiliation: Centre de Recherche en Cancerologie de Marseille (CRCM), CNRS, UMR7258; Institut Paoli Calmettes; Aix-Marseille Universite, UM 105; Inserm, U1068, F-13009, Marseille, France.
Squalamine, a natural aminosterol compound isolated from the dogfish shark Squalus acanthias, is reported to
possess high antimicrobial activities. Herein, we assessed its in vitro genotoxic properties by using the Ames test and the
micronucleus assay. All the experimental results demonstrate that squalamine is a non genotoxic molecule and call for further
work to evaluate its potent human therapeutic use as a new class of antinfectious agents.
Keywords: Ames test, antimicrobial agent, non-genotoxic, squalamine.
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