Abstract
Peripheral artery disease (PAD) produces significant disability attributable to lower extremity ischemia. Limited treatment modalities exist to ameliorate clinical symptoms in patients with PAD. Growing evidence links microRNAs to key processes that govern disease expression in PAD including angiogenesis, endothelial function, inflammation, vascular regeneration, vascular smooth muscle cell function, restenosis, and mitochondrial function. MicroRNAs have been identified in circulation and may serve as novel biomarkers in PAD. This article reviews the potential contribution of microRNA to key pathways of disease development in PAD that may lead to microRNA-based diagnostic and therapeutic approaches.
Keywords: Biomarker, peripheral arterial disease, epigenetics.
Current Vascular Pharmacology
Title:Therapeutic Potential of Modulating MicroRNA in Peripheral Artery Disease
Volume: 13 Issue: 3
Author(s): Naomi M. Hamburg and Nicholas J. Leeper
Affiliation:
Keywords: Biomarker, peripheral arterial disease, epigenetics.
Abstract: Peripheral artery disease (PAD) produces significant disability attributable to lower extremity ischemia. Limited treatment modalities exist to ameliorate clinical symptoms in patients with PAD. Growing evidence links microRNAs to key processes that govern disease expression in PAD including angiogenesis, endothelial function, inflammation, vascular regeneration, vascular smooth muscle cell function, restenosis, and mitochondrial function. MicroRNAs have been identified in circulation and may serve as novel biomarkers in PAD. This article reviews the potential contribution of microRNA to key pathways of disease development in PAD that may lead to microRNA-based diagnostic and therapeutic approaches.
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Cite this article as:
Hamburg M. Naomi and Leeper J. Nicholas, Therapeutic Potential of Modulating MicroRNA in Peripheral Artery Disease, Current Vascular Pharmacology 2015; 13 (3) . https://dx.doi.org/10.2174/15701611113119990014
DOI https://dx.doi.org/10.2174/15701611113119990014 |
Print ISSN 1570-1611 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6212 |
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