Peripheral artery disease (PAD) produces significant disability attributable to lower extremity
ischemia. Limited treatment modalities exist to ameliorate clinical symptoms in patients with PAD.
Growing evidence links microRNAs to key processes that govern disease expression in PAD including
angiogenesis, endothelial function, inflammation, vascular regeneration, vascular smooth muscle cell
function, restenosis, and mitochondrial function. MicroRNAs have been identified in circulation and
may serve as novel biomarkers in PAD. This article reviews the potential contribution of microRNA to
key pathways of disease development in PAD that may lead to microRNA-based diagnostic and therapeutic approaches.