Abstract
Bacterial biofilms are defined as a surface attached community of bacteria embedded in a matrix of extracellular polymeric substances that they have produced. When in the biofilm state, bacteria are more resistant to antibiotics and the host immune response than are their planktonic counterparts. Biofilms are increasingly recognized as being significant in human diseases such as; lung infections of cystic fibrosis (CF), colitis, urethritis, conjunctivitis, otitis, endocarditis, and periodontitis. Given the prominence of biofilms in infectious diseases, there has been an increased effort toward the development of small molecules that will modulate bacterial biofilm development and maintenance. In this review, we highlight the development of small molecules that inhibit and/or disperse bacterial biofilms through non-microbicidal mechanisms. The review provides a general overview of how bacteria develop into biofilm communities, why they are important, and the regulation of this process by quorum sensing. This is followed by a discussion of the numerous small molecules that have been identified as possessing the ability to control biofilm development.
Keywords: Bacteria, biofilm, biological activity, medicinal chemistry, natural products, non-microbicidal, structure-activityrelationship.
Anti-Infective Agents
Title:Non-Microbicidal Control of Bacterial Biofilms with Small Molecules
Volume: 12 Issue: 1
Author(s): Roberta J. Worthington, Justin J. Richards and Christian Melander
Affiliation:
Keywords: Bacteria, biofilm, biological activity, medicinal chemistry, natural products, non-microbicidal, structure-activityrelationship.
Abstract: Bacterial biofilms are defined as a surface attached community of bacteria embedded in a matrix of extracellular polymeric substances that they have produced. When in the biofilm state, bacteria are more resistant to antibiotics and the host immune response than are their planktonic counterparts. Biofilms are increasingly recognized as being significant in human diseases such as; lung infections of cystic fibrosis (CF), colitis, urethritis, conjunctivitis, otitis, endocarditis, and periodontitis. Given the prominence of biofilms in infectious diseases, there has been an increased effort toward the development of small molecules that will modulate bacterial biofilm development and maintenance. In this review, we highlight the development of small molecules that inhibit and/or disperse bacterial biofilms through non-microbicidal mechanisms. The review provides a general overview of how bacteria develop into biofilm communities, why they are important, and the regulation of this process by quorum sensing. This is followed by a discussion of the numerous small molecules that have been identified as possessing the ability to control biofilm development.
Export Options
About this article
Cite this article as:
Worthington Roberta J., Richards Justin J. and Melander Christian, Non-Microbicidal Control of Bacterial Biofilms with Small Molecules, Anti-Infective Agents 2014; 12 (1) . https://dx.doi.org/10.2174/22113525113119990107
DOI https://dx.doi.org/10.2174/22113525113119990107 |
Print ISSN 2211-3525 |
Publisher Name Bentham Science Publisher |
Online ISSN 2211-3533 |
Call for Papers in Thematic Issues
An Overview of Drugs for Multiple Targets and Variants of SARS-CoV-2 Through Artificial Intelligence, Machine Learning, Deep Learning, and Experimental Analysis
The emergence and rapid evolution of SARS-CoV-2 variants have posed significant challenges in the ongoing fight against the COVID-19 pandemic. The development of effective treatments for multiple viral targets and variants demands innovative approaches, including artificial intelligence (AI), machine learning (ML), and deep learning (DL) techniques. This special issue aims ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
'Mucormycosis': A Fungal Infection Threatening India During
COVID-19' - A Review
Anti-Infective Agents Odontogenic Infections in the Etiology of Infective Endocarditis
Cardiovascular & Hematological Disorders-Drug Targets The Radionuclide Molecular Imaging and Therapy of Neuroendocrine Tumors
Current Cancer Drug Targets Drug-Induced Thromboembolic Events in Patients with Malignancy
Cardiovascular & Hematological Disorders-Drug Targets Heart Disease in Patients with HIV/AIDS-An Emerging Clinical Problem
Current Cardiology Reviews Strategies for Antimicrobial Drug Delivery to Biofilm
Current Pharmaceutical Design Pulmonary Embolism Response Team (PERT) - A New Paradigm for the Treatment of Pulmonary Embolism
Current Pharmaceutical Design Prevention of Cardiovascular Complications in the Marfan Syndrome
Vascular Disease Prevention (Discontinued) Extracellular Enzymes Production and Biofilm Formation in Rhodotorula Species
Current Enzyme Inhibition Development and Validation of A Stability-Indicating Mekc Method for Determination of Flucloxacillin Sodium in Capsules
Current Analytical Chemistry Oral Infection and Vascular Disease
Vascular Disease Prevention (Discontinued) Human Heart Failure: A Proteomics Perspective
Current Proteomics The Guanylyl Cyclase Inhibition by MB as Vasoplegic Circulatory Shock Therapeutical Target
Current Drug Targets Pre-clinical Impact of the Synergistic Mechanism of Daptomycin and Ceftaroline on Patients with Methicillin-resistant Staphylococcus aureus Bacteremia Infections
Current Reviews in Clinical and Experimental Pharmacology Systemic Inflammatory Response as a Risk and Prognosis Factor in Ventilator-Associated Pneumonia
Current Respiratory Medicine Reviews New Synthetic Antibiotics for the Treatment of Enterococcus and Campylobacter Infection
Current Topics in Medicinal Chemistry Glycoprotein Targeting and Other Applications of Lectins in Biotechnology
Current Protein & Peptide Science Stability Assessment of Extemporaneous Formulation of Amoxicillin for Parenteral Antimicrobial Therapy
Current Pharmaceutical Analysis Can Infectious Biofilm be Controlled by Blocking Bacterial Communication?
Medicinal Chemistry In Vitro Synergistic Action of Certain Combinations of Gentamicin and Essential Oils
Current Medicinal Chemistry