Overcoming the Blood-Brain Barrier for Chemotherapy: Limitations, Challenges and Rising Problems
Juan Sebastian Yakisich.
Treatment of brain tumors with chemotherapy is limited mostly because of delivery impediments related to the blood-brain
barrier (BBB). For gliomas, the most common and aggressive primary brain tumor, treatment includes surgery, radiotherapy, and
chemotherapy usually administered orally or intravenously. These routes do not deliver effective concentrations. To complicate matters,
chemotherapy is usually a long treatment. Therefore, transient disruption of the BBB is likely insufficient to deliver effective intratumoral
concentrations of anticancer drugs. This review briefly updates current strategies for overcoming the BBB with emphasis on their
limitations and challenges intrinsic to the biology of cancer cells.
Keywords: Anticancer drugs, blood brain barrier, brain tumor, chemotherapy, gliomas.
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