Natural Compounds with Cell Growth Inhibitory Activity in Human Tumor Cell Lines

Author(s): Cristiane M. Cazal , Kantima Choosang , Vanessa Gisele P. Severino , João B. Fernandes , Maria Fátima G. F. da Silva , Paulo C. Vieira , Maria S. J. Nascimento , Gabriela M. Almeida , M. Helena Vasconcelos , Pannee Pakkong , Madalena M. M. Pinto .

Journal Name: Anti-Cancer Agents in Medicinal Chemistry

Volume 13 , Issue 10 , 2013

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Abstract:

Twenty six compounds (coumarins, flavonoids and alkaloids) were evaluated for their ability to inhibit the growth of three human tumor cell lines: breast adenocarcinoma (MCF-7), non-small cell lung cancer (NCI-H460) and melanoma (A375-C5). Three of them [3-hydroxyflavone (6), 2’-hydroxy-3,4,4’,5,6’-pentamethoxychalcone (11), Siderin (20)] were very potent in inhibiting all human tumor cell lines tested. The structure / activity relationship is discussed.

Keywords: Alkaloids, coumarins, flavonoids, tumor cell lines growth inhibitor.

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Article Details

VOLUME: 13
ISSUE: 10
Year: 2013
Page: [1582 - 1589]
Pages: 8
DOI: 10.2174/1871520613666131125122857
Price: $58

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