Letters in Drug Design & Discovery

G. Perry
University of Texas
San Antonio, TX
USA
Email: lddd@benthamscience.org

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Inhibitory Effects of Substituted Cinnamic Acid Esters on Mushroom Tyrosinase

Author(s): Zhenghua Zhang, Jinbing Liu, Fengyan Wu, Liangzhong Zhao.

Abstract:

A series of substituted cinnamic acid esters were synthesized and their inhibitory effects on the diphenolase activity of mushroom tyrosinase were evaluated. Compound 8 was found to be the most potent inhibitor with IC50 value of 5.60µM. Preliminary structure activity relationships (SARs) were concluded. The inhibition kinetics analyzed by Lineweaver–Burk plots revealed that compound 8 was anti-competitive inhibitor.

Keywords: Substituted cinnamic acid esters, Tyrosinase inhibitor, Synthesis, Structure activity relationships, Inhibition kinetics, Anti-competitive inhibitor.

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Article Details

VOLUME: 10
ISSUE: 6
Year: 2013
Page: [529 - 534]
Pages: 6
DOI: 10.2174/1570180811310060009
Price: $58