Design, Synthesis and Evaluation of Arylidene Pyrrolo and Pyrido Fused Quinazolones as Antimicrobial Agents
Preet Mohinder Singh Bedi,
Kanaya Lal Dhar.
Keeping in view the potential of heterocyclic fused quinazolones and arylidene linked heterocycles , hybrid
molecules of these functionalities were designed and synthesised. All the synthesised molecules were characterized by
spectroscopic techniques and evaluated for antimicrobial activity against 2 Gram positive bacterial strains; Staphylococcus
aureus (MTCC 96) and Bacillus subtilis (MTCC 2451), 3 Gram negative bacterial strains; Escherichia coli (MTCC 82),
Pseudomonas aeruginosa (MTCC 2642) and Salmonella typhimurium (MTCC 1251) and 2 fungal strains; Saccharomyces
cerevisiae (MTCC 2799) and Candida albicans (MTCC 3018). Among the synthesised molecules, arylidene pyrrolo fused
quinazolones displayed significant antimicrobial activity in comparison to arylidene pyrido fused quinazolones. The influence
of the electronic factors linked with the arylidene ring was also observed on the antimicrobial potential. Thus the
present study highlights the potential of such hybrid molecules as a new class of antimicrobials.
Keywords: Antimicrobial, Quinazoline, Strains, Quinazoline, Pyrrolo, Pyrido.
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