Letters in Drug Design & Discovery

G. Perry
University of Texas
San Antonio, TX
Email: lddd@benthamscience.org


Diversity in Antibacterial Activity of Thiosemicarbazides Derived from 3-Chlorobenzhydrazide

Author(s): Tomasz Plech, Monika Wujec, Urszula Kosikowska, Anna Malm.


3-Chlorobenzoic acid hydrazide was reacted with different aryl isothiocyanates to give the corresponding 1-(3- chlorobenzoyl)-4-substituted thiosemicarbazides 1-16. Reaction yields ranged from 74 to 96%. Structures of the synthesized compounds were defined on the basis of 1H NMR and IR spectra. As it was showed the antibacterial activity of the obtained compounds was limited only towards Gram-positive bacteria. As regards B. cereus ATCC 10876, 1-(3- chlorobenzoyl)-4-(3,5-dichlorophenyl)thiosemicarbazide (8) was 16 times more active than ampicillin and 8 times more active than cefuroxime.

Keywords: Hydrazides, Structure-activity relationships, MIC, MRSA.

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Article Details

Year: 2013
Page: [492 - 496]
Pages: 5
DOI: 10.2174/1570180811310060004
Price: $58