Synthesis and Antimicrobial Evaluation of Some 2,5-Disubstituted Benzimidazole Derivatives
Zafer Asim Kaplancıkli.
Some benzimidazole derivatives bearing hydrazone moiety were synthesized and their in vitro antimicrobial activity
was determined against various gram-positive and gram-negative bacteria, and fungi using microbroth dilution
method. The structures of all new compounds were identified by1H-NMR, FT-IR, MS spectroscopic techniques and elemental
analysis. Sixteen final products were examined for their in vitro antimicrobial activities. When compared to the
reference agents, chloramphenicol and ketoconazole, most of the synthesized compounds showed sufficient antibacterial
activity against Pseudomonas aeruginosa and antifungal activity against Candida albicans and C. glabrata.
Keywords: Benzimidazole, Hydrazone, Antibacterial activity, Antifungal activity.
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