Synthesis and Antimicrobial Evaluation of Some 2,5-Disubstituted Benzimidazole Derivatives

Author(s): Leyla Yurttas, Yusuf Ozkay, Hulya Karaca, Yagmur Tunali, Zafer Asim Kaplancıkli.

Journal Name: Letters in Drug Design & Discovery

Volume 10 , Issue 6 , 2013

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Some benzimidazole derivatives bearing hydrazone moiety were synthesized and their in vitro antimicrobial activity was determined against various gram-positive and gram-negative bacteria, and fungi using microbroth dilution method. The structures of all new compounds were identified by1H-NMR, FT-IR, MS spectroscopic techniques and elemental analysis. Sixteen final products were examined for their in vitro antimicrobial activities. When compared to the reference agents, chloramphenicol and ketoconazole, most of the synthesized compounds showed sufficient antibacterial activity against Pseudomonas aeruginosa and antifungal activity against Candida albicans and C. glabrata.

Keywords: Benzimidazole, Hydrazone, Antibacterial activity, Antifungal activity.

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Article Details

Year: 2013
Page: [486 - 491]
Pages: 6
DOI: 10.2174/1570180811310060003
Price: $58

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