Synthesis of New Compounds Combining Adamantanamine and Monoterpene Fragments and their Antiviral Activity Against Influenza Virus A(H1N1)pdm09

Author(s): George V. Teplov , Evgeny V. Suslov , Vladimir V. Zarubaev , Anna A. Shtro , Liubov A. Karpinskaya , Artem D. Rogachev , Dina V. Korchagina , Konstantin P. Volcho , Nariman F. Salakhutdinov , Oleg I. Kiselev .

Journal Name: Letters in Drug Design & Discovery

Volume 10 , Issue 6 , 2013

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Abstract:

A set of new nitrogen-containing compounds with adamantane and monoterpene frameworks was synthesized. The antiviral activity of the amine products against the influenza virus A/California/07/09 (H1N1)pdm09 was studied. The introduction of a monoterpenoid fragment led to increase of the antiviral activity of adamantylamine derivatives against adamantylamine resistant virus: the selectivity index of the majority of the synthesized amines was higher than that of rimantadine and amantadine.

Keywords: Adamantyamine, Antiviral, (H1N1)pdm09, Influenza, Monoterpenoid, Resistance.

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Article Details

VOLUME: 10
ISSUE: 6
Year: 2013
Page: [477 - 485]
Pages: 9
DOI: 10.2174/1570180811310060002
Price: $58

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