Letters in Drug Design & Discovery

G. Perry
University of Texas
San Antonio, TX
Email: lddd@benthamscience.org


Synthesis of New Compounds Combining Adamantanamine and Monoterpene Fragments and their Antiviral Activity Against Influenza Virus A(H1N1)pdm09

Author(s): George V. Teplov, Evgeny V. Suslov, Vladimir V. Zarubaev, Anna A. Shtro, Liubov A. Karpinskaya, Artem D. Rogachev, Dina V. Korchagina, Konstantin P. Volcho, Nariman F. Salakhutdinov, Oleg I. Kiselev.


A set of new nitrogen-containing compounds with adamantane and monoterpene frameworks was synthesized. The antiviral activity of the amine products against the influenza virus A/California/07/09 (H1N1)pdm09 was studied. The introduction of a monoterpenoid fragment led to increase of the antiviral activity of adamantylamine derivatives against adamantylamine resistant virus: the selectivity index of the majority of the synthesized amines was higher than that of rimantadine and amantadine.

Keywords: Adamantyamine, Antiviral, (H1N1)pdm09, Influenza, Monoterpenoid, Resistance.

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Article Details

Year: 2013
Page: [477 - 485]
Pages: 9
DOI: 10.2174/1570180811310060002
Price: $58