Pancreatic cancer has a poor prognosis, with only 10% survival one year following diagnosis. Despite
significant advances in conventional therapies (chemotherapy and radiotherapy), little improvement in patient survival
has occurred in the last decade. Therefore, there is a critical need for novel and effective therapeutic approaches for
this cancer. This article reviews current concepts in the pathogenesis and treatment of pancreatic cancer, the latter
including tumor resection approaches and the current standard of care. We further describe recent advances in new and
combination therapies, which result only in modest increases in survival, and discuss challenges in drug delivery and
Keywords: Chemotherapy, pancreatic cancer, side-effects, stroma, targeted therapy.
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