Over the last few decades, numerous articles dealing with acridine have been reported providing solid
background for drug design. Interest in thioacridine/thioacridone derivatives is demonstrated by their use against varied
pharmacological activities. The article summarizes the synthetic routes of thioacridine/thioacridone and wide range of
their uses including receptor interaction, enzyme inhibition, anti-proliferative effects, anti-microbial activity, etc. The first
synthetic route for thioacridone includes the use of acridone with sulfur at high temperature. In order to improve the yield
and the laborious reaction conditions other new synthetic methodologies were developed. It has been multi substituted
with variety of functional groups which have a substantial impact on their biological activities. The diversity in the
biological response has prompted researchers to explore this skeleton to its potential against several activities. Our aim is
to review the most promising therapeutic developments dealing with thioacridine/thioacridone derivatives by pinpointing
the new trends and the promising therapeutic directions.
Keywords: Biological activity, synthesis, thioacridine, thioacridone.
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