4-Aminoquinazoline Analogs: A Novel Class of Anticancer Agents

Author(s): Kalpana Singh , P.P. Sharma , A. Kumar , Anurag Chaudhary , R.K. Roy .

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 13 , Issue 8 , 2013

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Abstract:

4-Aminoquinazoline analogs have been identified as a new class of cancer chemotherapeutic agents with significant therapeutic efficacy against solid tumors. They are potent and highly selective inhibitors of tyrosine kinase (TK) and epidermal growth factor receptor (EGFR). Till date various 4-aminoquinazoline analogs have been synthesized and evaluated for anticancer activity. This review is an attempt to compile the medicinal chemistry of various synthesized 4-aminoquinazoline analogs.

Keywords: 4-Aminoquinazoline, antitumor, apoptosis, cytotoxic, epidermal growth factor receptor, tyrosine kinase.

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Article Details

VOLUME: 13
ISSUE: 8
Year: 2013
Page: [1177 - 1194]
Pages: 18
DOI: 10.2174/1389557511313080006
Price: $58

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