Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry

(Formerly Current Medicinal Chemistry - Anti-Inflammatory & Anti-Allergy Agents)

Bahar Tunctan
Department of Pharmacology
Faculty of Pharmacy
Mersin University
Mersin, 33169
Turkey

Back

MicroRNA: Novel Modulators of the Cholinergic Anti-Inflammatory Pathway

Author(s): Medha Priyadarshini, N.A. Arivarasu, Aaliya Shah, Shams Tabrez, Shubha Priyamvada, Mohd. Aatif.

Abstract:

MicroRNAs (miRNAs) have emerged as key gene regulators controlling the expression of many target mRNAs. The nervous system harbors highest number of miRNAs expressed in a spatially and temporally controlled manner. Neural miRNAs have been accredited with diverse roles like regulation of neural differentiation, synaptogenesis, inflammation, memory and cognition. Their aberrant expression and/or function has been linked to various neurodegenerative, neuroinflammatory and stress related disorders. Recent evidence indicates that miRNAs are essential to the fine tuning of the immune responses. Besides controlling the maturation, proliferation and differentiation of myeloid and lymphoid lineages they participate directly by modulating the signaling pathways through the Toll-like receptors and thus the cytokine response. The miRNAs commuting between the nervous and immune systems and affecting the neuro-immune dialogue are emerging.

Keywords: Acetylcholinestrase, α7 acetylcholine receptor, cholinergic anti-inflammatory pathway, microRNA, miR-132, vagus nerve.

Order Reprints Order Eprints Rights & PermissionsPrintExport

Article Details

VOLUME: 12
ISSUE: 2
Year: 2013
Page: [136 - 140]
Pages: 5
DOI: 10.2174/1871523011312020005
Price: $58