Fluorinated Tropanes

Author(s): Jeffrey S. Stehouwer.

Journal Name: Current Topics in Medicinal Chemistry

Volume 13 , Issue 8 , 2013

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Abstract:

The development of tropane-derivatives as cocaine-addiction therapeutics identified numerous compounds with affinities for the dopamine, serotonin, and norepinephrine transporters. Many of these compounds were then adapted for use as imaging radiotracers. Incorporation of fluorine into the molecule often improved the physiochemical properties of the compound and also provided a position for radiolabeling with fluorine-18. This review provides an overview of the efforts devoted to developing fluorine-18 radiolabeled tropanes for imaging use with positron emission tomography.

Keywords: Fluorine-18, positron emission tomography, tropane, nortropane, dopamine transporter, serotonin transporter, norepinephrine transporter.

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Article Details

VOLUME: 13
ISSUE: 8
Year: 2013
Page: [920 - 935]
Pages: 16
DOI: 10.2174/1568026611313080005
Price: $58

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