Cellular and Pharmacological Targets to Induce Coronary Arteriogenesis

Maurits   R.   Hollander; Anton   J.G.   Horrevoets; Niels   van   Royen

Abstract

The formation of collateral vessels (arteriogenesis) to sustain perfusion in ischemic tissue is native to the body and can compensate for coronary stenosis. However, arteriogenesis is a complex process and is dependent on many different factors. Although animal studies on collateral formation and stimulation show promising data, clinical trials have failed to replicate these results. Further research to the exact mechanisms is needed in order to develop a pharmalogical stimulant. This review gives an overview of recent data in the field of arteriogenesis.

Keywords: Arteriogenesis, CAD, collateral, endothelium, growth factors, proliferation, SMC.