Cellular and Pharmacological Targets to Induce Coronary Arteriogenesis
Maurits R. Hollander, Anton J.G. Horrevoets and Niels van Royen
Affiliation: VU University Medical Center, Department of Cardiology, Room 4D-36, de Boelelaan 1117, 1081 HV Amsterdam, The Netherlands.
Keywords: Arteriogenesis, CAD, collateral, endothelium, growth factors, proliferation, SMC.
The formation of collateral vessels (arteriogenesis) to sustain perfusion in ischemic tissue is native to the body
and can compensate for coronary stenosis. However, arteriogenesis is a complex process and is dependent on many different
factors. Although animal studies on collateral formation and stimulation show promising data, clinical trials have
failed to replicate these results. Further research to the exact mechanisms is needed in order to develop a pharmalogical
stimulant. This review gives an overview of recent data in the field of arteriogenesis.
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