P2O5/SiO2 : A Simple and Effective Catalyst for the Synthesis of N-substituted 1-Alkyl and 1-Aryl 3-Aminoisoquinolines

Author(s): Leticia J. Méndez, Alicia S. Cánepa, Ruben Rimada, Rodolfo D. Bravo.

Journal Name: Letters in Organic Chemistry

Volume 10 , Issue 4 , 2013

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A synthesis of N-substituted 1-alkyl and 1-aryl 3-aminoisoquinolines by cyclocondensation of 2- acylphenylacetonitriles with aliphatic and aromatic amines using P2O5/SiO2 as catalysts is described. Selectivity, simplicity of operation and easy work-up are some advantages of this method.

Keywords: P2O5/SiO2, 3-aminoisoquinolines, 2-acylphenylacetonitriles.

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Article Details

Year: 2013
Page: [240 - 244]
Pages: 5
DOI: 10.2174/1570178611310040003
Price: $65

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