An efficient synthesis of new spiro[chroman-3,6'-furo[2,3-d]pyrimidine]- tetraones by an organocatalyzed
three-component condensation reaction of aldehydes, barbituric acids and 3-bromo-4-hydroxy-2H-chromen-2-one in
refluxing acetic acid in the presence of 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) is reported. We are hopeful that the
products will lead to a wider range pharmacological and physiological activity.
Keywords: Barbituric acid, coumarine, spirochroman-furopyrimidine.
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