An Efficient One-Pot Organocatalyzed Synthesis of Spiro[Chroman-3,6'- Furo[2,3-d]Pyrimidine]-Tetraones

Author(s): Somayeh Ahadi, Peiman Mirzaei, Ayoob Bazgir.

Journal Name: Combinatorial Chemistry & High Throughput Screening

Volume 16 , Issue 6 , 2013

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Abstract:

An efficient synthesis of new spiro[chroman-3,6'-furo[2,3-d]pyrimidine]- tetraones by an organocatalyzed three-component condensation reaction of aldehydes, barbituric acids and 3-bromo-4-hydroxy-2H-chromen-2-one in refluxing acetic acid in the presence of 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) is reported. We are hopeful that the products will lead to a wider range pharmacological and physiological activity.

Keywords: Barbituric acid, coumarine, spirochroman-furopyrimidine.

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Article Details

VOLUME: 16
ISSUE: 6
Year: 2013
Page: [435 - 440]
Pages: 6
DOI: 10.2174/1386207311316060003
Price: $58

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