Role of Innate Immune System in Inflammation and Cardiac Remodeling After Myocardial Infarction

Author(s): Masafumi Takahashi.

Journal Name: Current Vascular Pharmacology

Volume 13 , Issue 1 , 2015

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Abstract:

The innate immune system is well recognized as the first line defense of foreign pathogens; however, it can also recognize endogenous signals released from injured tissues and induce sterile inflammation. Toll-like receptors (TLRs) and Nod-like receptors (NLRs) have been identified as its receptors, and they have been shown to play a key role in the disease processes of sterile inflammation, including myocardial infarction (MI). In particular, NLRs are the key components of the caspase-1 activating platform known as the “inflammasome,” which produces the potent proinflammatory cytokine interleukin-1β. The current article reviews the role of the innate immune system, especially TLRs and inflammasomes, in the pathophysiology of MI.

Keywords: Cytokine, inflammasome, ischemia, nod-like receptor, reperfusion, toll-like receptor.

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Article Details

VOLUME: 13
ISSUE: 1
Year: 2015
Page: [20 - 25]
Pages: 6
DOI: 10.2174/15701611113119990007

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