Orthopaedic joint implants and osteosynthetic materials are progressively being employed more often. Complications
mainly include physical-mechanical problems and infections. Uncommonly, allergic reactions to an alloy metal or
a bone cement component have been implicated. Less attention has been paid to the components of bone cement, such as
acrylate, catalysers (e.g. peroxide), additive polymers or stabilisers. An important bone cement component is benzoylperoxide
(BPO), an initiator of the process enhancement of the bone cement. Vitiligo is an acquired, progressive depigmenting
disorder that can induce autoimmune diseases. The occurrence of vitiligo in combination with an infection or allergy
is not well described, and this manuscript highlights the possibility of an occurrence of a vitiligo whenever the immunesystem
is activated and T-cell activation is observed. The aim of this article was to analyze the diagnosis and management
of vitiligo and allergic complications from orthopaedic joint implants due to benzoyl-peroxide and relevant patents.
Keywords: Allergy, benzoyl-peroxide, bone-cement, infection of joint replacement, knee joint replacement, vitiligo.
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