Inflammation is the propitious response of vascular tissue to pathogens, damaged cells or irritants. Recent
discoveries on the molecular and cellular basis of inflammation and allergy have markedly altered the understanding of
these disorders. Although the conventional therapy used for the treatment of autoimmune and inflammatory diseases has
improved the condition of patients but it has also placed them at the stake of enormous side effects. In recent times, the
usage of Mesenchymal Stem Cell (MSC) therapy in the field of medical science has provided better alternative, concomitant
treatment for these diseases as suggested by preclinical studies. Thus, in this review we have summarized the recent findings
on MSCs as a therapeutic agent in treating inflammatory disorders using novel methods. This review also outlines the
current state of knowledge on the biology of MSCs and their use as a suitable candidate for cell-based therapeutics. In
addition, we focus on various patents, in which administration of MSC attenuates inflammation and injury thereby
suggesting its integral role in host immune response, immunomodulation and anti-inflammation, which may in turn lead
to novel patents in this field in the future.
Keywords: Anti-inflammatory, autoimmune disorders, immunemodulators, mesenchymal stem cells (MSCs), stem cells,
umbilical cord derived mesenchymal stem cells.
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