Mitochondria and Familial Predisposition to Breast Cancer

Author(s): Stefania Weigl, Angelo Paradiso, Stefania Tommasi.

Journal Name: Current Genomics

Volume 14 , Issue 3 , 2013

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Abstract:

Mitochondrial genome and functional alterations are related to various diseases including cancer. In all cases, the role of these organelles is associated with defects in oxidative energy metabolism and control of tumor-induced oxidative stress. The present study examines the involvement of mitochondrial DNA in cancer and in particular in breast cancer. Furthermore, since mitochondrial DNA is maternally inherited, hereditary breast cancer has been focused on.

Keywords: Mitochondrial DNA, Hereditary breast cancer, DNA variations, Polymorphism, Mitochondrial haplogroup.

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Article Details

VOLUME: 14
ISSUE: 3
Year: 2013
Page: [195 - 203]
Pages: 9
DOI: 10.2174/1389202911314030005
Price: $58

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