Abstract
Mitochondrial genome and functional alterations are related to various diseases including cancer. In all cases, the role of these organelles is associated with defects in oxidative energy metabolism and control of tumor-induced oxidative stress. The present study examines the involvement of mitochondrial DNA in cancer and in particular in breast cancer. Furthermore, since mitochondrial DNA is maternally inherited, hereditary breast cancer has been focused on.
Keywords: Mitochondrial DNA, Hereditary breast cancer, DNA variations, Polymorphism, Mitochondrial haplogroup.
Current Genomics
Title:Mitochondria and Familial Predisposition to Breast Cancer
Volume: 14 Issue: 3
Author(s): Stefania Weigl, Angelo Paradiso and Stefania Tommasi
Affiliation:
Keywords: Mitochondrial DNA, Hereditary breast cancer, DNA variations, Polymorphism, Mitochondrial haplogroup.
Abstract: Mitochondrial genome and functional alterations are related to various diseases including cancer. In all cases, the role of these organelles is associated with defects in oxidative energy metabolism and control of tumor-induced oxidative stress. The present study examines the involvement of mitochondrial DNA in cancer and in particular in breast cancer. Furthermore, since mitochondrial DNA is maternally inherited, hereditary breast cancer has been focused on.
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Cite this article as:
Weigl Stefania, Paradiso Angelo and Tommasi Stefania, Mitochondria and Familial Predisposition to Breast Cancer, Current Genomics 2013; 14 (3) . https://dx.doi.org/10.2174/1389202911314030005
DOI https://dx.doi.org/10.2174/1389202911314030005 |
Print ISSN 1389-2029 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5488 |
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