Cardiovascular & Hematological Agents in Medicinal Chemistry

(Formerly Current Medicinal Chemistry - Cardiovascular & Hematological Agents)

Debabrata Mukherjee
Department of Internal Medicine Texas Tech University
4800 Alberta Avenue El Paso
Texas, 79905


Low - Molecular Weight Heparins and Unfractionated Heparins during Primary Coronary Intervention

Author(s): Chiara Cavallino, Matteo Santagostino, Emanuela Facchini, Virginia Di Ruocco and Andrea Rognoni

Affiliation: Coronary Care Unit and Catheterization Laboratory, Hospital “Maggiore della Carita”, Corso Mazzini 18, 28100 Novara, Italy.


Coronary artery diseases continue to be the most common causes of mortality and morbidity in the industrialized world, especially in the setting of acute myocardial infarction.

Anticoagulation during primary percutaneous coronary intervention (PCI) for ST-elevation myocardial infarction (STEMI) has traditionally been supported by anticoagulant unfractionated heparin (UFH). Recently, alternative anticoagulants such as low molecular weight heparin (LMWH) were included in the management of STEMI.

The aim of the present review is to compare efficacy and safety outcomes among patients receiving low molecular weight heparins (LMWH) or unfractionated heparin (UFH) while undergoing PCI for STEMI.

Keywords: STEMI, PCI, low-molecular weight heparins, unfractionated heparin, acute coronary syndromes, thrombosis, in – stent restenosis, bleeding, coronary intervention, adjuvant therapy.

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Article Details

Page: [96 - 100]
Pages: 5
DOI: 10.2174/1871525711311020004