Fibrocytes in the Pathogenesis of Chronic Fibrotic Lung Disease
Bethany B. Moore.
Fibrocytes were initially described in 1999 and since that time there has been a growing body of literature to
suggest their importance in a number of chronic lung diseases. It is now well established that fibrocytes derive from the
bone marrow and circulate within the peripheral blood. However, when injury occurs, fibrocytes can travel to the site of
damage via chemokine-mediated recruitment. Recent studies suggest that fibrocyte numbers increase within the lung or
circulation during numerous disease processes. Although fibrocytes readily differentiate into fibroblasts in vitro, whether
they do so readily in vivo is still unclear. Additionally, while human studies often show evidence of α-smooth muscle
actin (SMA) expression in fibrocytes, this is less common in murine studies. A variety of pro-fibrotic mediators that are
secreted by fibrocytes make it likely that they can act via paracrine functions to influence the behavior of resident lung
cells. This review summarizes recent insights regarding fibrocytes in asthma, scleroderma and IPF.
Keywords: Bone marrow, chemokines, fibroblasts, fibrocytes, fibrosis, lung.
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