Current Respiratory Medicine Reviews

Joseph Varon  
The University of Texas Health Science Center
Houston, TX


Pulmonary Function Tests in European Birth Cohorts

Author(s): Linus Grabenhenrich, Cynthia Hohmann, Remy Slama, Joachim Heinrich, Magnus Wickman, Carel Thijs, Kai-Hakon Carlsen, Karin Lodrup Carlsen, Susanne Lau, Thomas Keil.


Pulmonary function tests are commonly used within research to characterize disease patterns of obstructive airway diseases, and to describe lung growth and development. 20 out of 52 European birth cohorts within the ENRIECOand GA2LEN-networks reported a total of 80 investigation time-points using pulmonary function assessments. Information on published results and guidelines used were complemented through publicly available data and peer reviewed journals. Only 4 cohorts used the same test for at least 3 time-points during their follow-up. The tests were used to classify airway obstruction, bronchodilator response and bronchial hyperresponsiveness. Related methods assessed airway inflammation non-invasively. International guidelines, used in clinical practice, (American Thoracic Society/ European Respiratory Society) should be considered and referred to whenever possible to improve comparability. A consensus on when and how pulmonary function tests are beneficial in population based research, assessing lung growth or asthma subtypes, is needed.

Keywords: Asthma, exhaled nitric oxide, guidelines, lung development, spirometry.

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Article Details

Year: 2013
Page: [3 - 10]
Pages: 8
DOI: 10.2174/1573398X11309010002