Vascular Endothelial Growth Factor Electro-Gene Therapy Improves Functional Outcome in a Mouse Model of ALS

Author(s): Tatsufumi Murakami , Yuki Shimada , Yoshimi Imada , Akihiro Nakamura , Yoshihide Sunada .

Journal Name: Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry (Under Re-organization)

Volume 13 , Issue 2 , 2013

Abstract:

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by selective loss of motor neurons. Vascular endothelial growth factor (VEGF) is a key mediator of angiogenesis, and has neurotrophic and neuroprotective activities. To examine the efficacy of VEGF electro-gene therapy for ALS, intramuscular mouse VEGF 164 gene transfer was performed by electroporation to treat a mouse model of ALS, transgenic Cu/Zn superoxide dismutase (SOD1) (G93A) mice. VEGF electro-gene therapy delayed the onset of decline in hindlimb function by more than 1 week, but did not significantly prolong survival in SOD1 transgenic mice, suggesting that continuous release of VEGF 164 by intramuscular electro-gene therapy is partially effective in the treatment of SOD1 transgenic mice.

Keywords: Amyotrophic lateral sclerosis, electroporation, gene therapy, grip strength, intramuscular injection, motor neuron, neuromuscular junction, rotarod test, transgenic SOD1 G93A mice, vascular endothelial growth factor.

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Article Details

VOLUME: 13
ISSUE: 2
Year: 2013
Page: [107 - 111]
Pages: 5
DOI: 10.2174/1871522211313020004
Price: $58

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